需要对每位患者进行长期观察的随机临床试验的设计与分析。II. 分析与示例。
Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. analysis and examples.
作者信息
Peto R, Pike M C, Armitage P, Breslow N E, Cox D R, Howard S V, Mantel N, McPherson K, Peto J, Smith P G
出版信息
Br J Cancer. 1977 Jan;35(1):1-39. doi: 10.1038/bjc.1977.1.
Abstract
Part I of this report appeared in the previous issue (Br. J. Cancer (1976) 34,585), and discussed the design of randomized clinical trials. Part II now describes efficient methods of analysis of randomized clinical trials in which we wish to compare the duration of survival (or the time until some other untoward event first occurs) among different groups of patients. It is intended to enable physicians without statistical training either to analyse such data themselves using life tables, the logrank test and retrospective stratification, or, when such analyses are presented, to appreciate them more critically, but the discussion may also be of interest to statisticians who have not yet specialized in clinical trial analyses.
摘要
本报告的第一部分发表于上一期（《英国癌症杂志》（1976年）第34卷，第585页），讨论了随机临床试验的设计。第二部分现在描述了随机临床试验的有效分析方法，在这些试验中，我们希望比较不同患者组之间的生存时间（或直到首次发生其他不良事件的时间）。其目的是使没有统计学培训的医生能够使用生命表、对数秩检验和回顾性分层自行分析此类数据，或者在呈现此类分析时，更批判性地理解它们，但对于尚未专门从事临床试验分析的统计学家来说，该讨论可能也会有兴趣。
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