Miller J M, Horger E O, Key T C, Walker E M
Am J Obstet Gynecol. 1981 Oct 1;141(3):237-41. doi: 10.1016/s0002-9378(16)32625-4.
During the past decade, pregnancy outcome has improved among patients with sickle hemoglobinopathies. The role of prophylactic exchange transfusion in this improvement is uncertain. This study reviews the experience in 64 pregnancies managed at the Medical University Hospital over a 7 year period. Prophylactic exchange transfusion was not associated with improved pregnancy outcome and was associated with significant antibody formation. Exchange transfusion may best be reserved as a treatment modality when infection, crisis, or symptomatic anemia occurs in patients with a sickle hemoglobinopathy.
在过去十年中，镰状血红蛋白病患者的妊娠结局有所改善。预防性换血疗法在这一改善过程中所起的作用尚不确定。本研究回顾了医科大学医院在7年期间对64例妊娠进行管理的经验。预防性换血疗法与改善妊娠结局无关，且与显著的抗体形成有关。当镰状血红蛋白病患者发生感染、危象或有症状性贫血时，换血疗法最好作为一种治疗方式保留使用。
