阿尔茨海默病：基底核中胆碱能神经元选择性丧失的证据。
Alzheimer disease: evidence for selective loss of cholinergic neurons in the nucleus basalis.
作者信息
Whitehouse P J, Price D L, Clark A W, Coyle J T, DeLong M R
出版信息
Ann Neurol. 1981 Aug;10(2):122-6. doi: 10.1002/ana.410100203.
PMID:7283399
Abstract
The nucleus basalis of Meynert provides diffuse cholinergic input to the neocortex. When compared with an age- and sex-matched control, the nucleus basalis from a patient with Alzheimer disease demonstrated substantial reduction of neurons. Loss of this neuronal population may represent an anatomical correlate of the well-documented cholinergic derangement in Alzheimer disease.
摘要
迈内特基底核向新皮层提供弥散性胆碱能输入。与年龄和性别匹配的对照相比，阿尔茨海默病患者的迈内特基底核显示神经元大量减少。这一神经元群体的丧失可能是阿尔茨海默病中充分记录的胆碱能紊乱的解剖学相关因素。
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