迟发性皮肤卟啉病中的基因组和染色体突变。

Genome and chromosome mutations in porphyria cutanea tarda.

作者信息

Lukanov L, Tsoneva M, Krachunova M, Ivanov E, Adjarov D

出版信息

Br J Dermatol. 1981 Aug;105(2):133-6. doi: 10.1111/j.1365-2133.1981.tb01197.x.

DOI:10.1111/j.1365-2133.1981.tb01197.x

Abstract

Spontaneous genome mutations in ten patients with porphyria cutanea tarda (PCT) amounted to 1.02% as compared to 0.36% in the control group of healthy individuals (P less than 0.01). Spontaneous structural chromosome aberrations in patients were seen in 2.39% of the examined cells versus 0.70% in the cells of controls (P less than 0.01). The increased percentage of cells with spontaneous genome and chromosome mutations in patients with PCT cannot be associated with alcohol only.

摘要

与健康个体对照组的0.36%相比，10例迟发性皮肤卟啉病（PCT）患者的自发基因组突变率达1.02%（P<0.01）。患者中2.39%的受检细胞出现自发染色体结构畸变，而对照组细胞中这一比例为0.70%（P<0.01）。PCT患者中具有自发基因组和染色体突变的细胞比例增加不能仅与酒精相关联。