Michaëlsson G, Bergqvist A, Vahlquist A, Vessby B
Br J Dermatol. 1981 Aug;105(2):201-5. doi: 10.1111/j.1365-2133.1981.tb01206.x.
Eight patients with psoriasis or Darier's disease were studied during 1-3 months of 'Tigason' treatment (0.7-0.8 mg/kg body weight). The levels of triglycerides and cholesterol in whole serum and in different lipoprotein fractions were repeatedly determined. Before treatment all lipid values were within the normal range. During treatment the values changed gradually and five of the eight patients developed pathological VLDL triglyceride concentrations. A significant increase of VLDL cholesterol and a decrease in the HDL cholesterol was also noted. Until more information is available, prolonged treatment periods with 'Tigason' should perhaps be avoided, at least in high risk patients.
八名患有银屑病或毛囊角化病的患者在接受1至3个月的“银屑灵”治疗（0.7至0.8毫克/千克体重）期间接受了研究。对全血清和不同脂蛋白组分中的甘油三酯和胆固醇水平进行了反复测定。治疗前，所有血脂值均在正常范围内。治疗期间，这些值逐渐变化，八名患者中有五名出现了病理性极低密度脂蛋白甘油三酯浓度。还注意到极低密度脂蛋白胆固醇显著增加，高密度脂蛋白胆固醇降低。在获得更多信息之前，或许应避免长期使用“银屑灵”进行治疗，至少对于高危患者应如此。
