[3H]-哇巴因在功能不同的犬心脏组织中的蓄积：Rb⁺摄取差异
Accumulation of [3H]-ouabain in functionally different canine cardiac tissues: differential Rb+ uptake.
作者信息
Rhee H M
出版信息
Br J Pharmacol. 1981 May;73(1):81-6. doi: 10.1111/j.1476-5381.1981.tb16774.x.
Abstract
1 In order to understand tissue-specific differences in sensitivity to ouabain, the distribution of [3H]-ouabain was investigated in seven functionally different, canine cardiac tissues. 2 Specialized cardiac tissues (e.g., pacemaker or conducting tissues) accumulate much less ouabain than do the contractile tissues such as the left ventricle or the papillary muscle. 3 This study confirms a greater Rb+ uptake in the Purkinje fibre than in the contractile tissue. 4 The results disprove the hypothesis that a high accumulation of ouabain in the Purkinje fibre is responsible for the well-known sensitivity to ouabain in this tissue.
摘要
- 为了了解不同组织对哇巴因敏感性的差异，研究了[3H] - 哇巴因在七种功能不同的犬心脏组织中的分布情况。2. 专门的心脏组织（如起搏组织或传导组织）积累的哇巴因比收缩性组织（如左心室或乳头肌）少得多。3. 本研究证实在浦肯野纤维中Rb + 的摄取比在收缩性组织中更高。4. 结果反驳了如下假说：浦肯野纤维中哇巴因的高积累是该组织对哇巴因众所周知的敏感性的原因。
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Accumulation of [3H]-ouabain in functionally different canine cardiac tissues: differential Rb+ uptake.[3H]-哇巴因在功能不同的犬心脏组织中的蓄积：Rb⁺摄取差异
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