Moulé Y, Douce C, Moreau S, Darracq N
Chem Biol Interact. 1981 Oct;37(1-2):155-64. doi: 10.1016/0009-2797(81)90172-1.
The effects of botryodiplodia, a mycotoxin synthesized by Botryodiplodia theobromae and by some strains of Penicillium roqueforti. The toxin inhibited cell multiplication in growing cultures at concentrations which were without toxic effect on cultures nearing or at confluence. In growing cultures the toxin affected DNA, RNA and protein synthesis, the effect on DNA synthesis being the greatest. The removal of mycotoxin from the culture medium brought about partial recovery of the synthetic activities of the cells. The implications of the results with respect of the recovery of DNA synthesis are discussed.
由可可球二孢菌（Botryodiplodia theobromae）和某些娄地青霉（Penicillium roqueforti）菌株合成的一种霉菌毒素——葡萄座腔菌素的作用。该毒素在对接近汇合或已汇合的培养物无毒性作用的浓度下，抑制生长中的培养物中的细胞增殖。在生长中的培养物中，该毒素影响DNA、RNA和蛋白质合成，对DNA合成的影响最大。从培养基中去除霉菌毒素可使细胞的合成活性部分恢复。讨论了这些结果对DNA合成恢复的意义。
