Groth T, Falk H, Westgard J O
Comput Programs Biomed. 1981 Mar-Jun;13(1-2):73-86. doi: 10.1016/0010-468x(81)90085-4.
A computer simulation program has been developed to aid in the design of statistical quality control procedures in clinical chemistry. This 'QC simulator' permits the user to study the effects of parameters in the analytical procedure (method standard deviation, components of variance, rounding of data) and parameters in the control procedure (choice of statistics, control limits, decision criteria, number of control observations). The performance of the control procedures being studied are characterized by their probability for ejection, estimated at several different levels of random and systematic error, and presented by plots of statistical power vs the size of the analytical errors. The relative performance of different control procedures can be compared based on these performance characteristics. Another important application of the program is in the design of control procedures to assure that a specified level of analytical quality is achieved in routine laboratory analyses. The utility of this interactive simulation tool is illustrated in two typical sample runs.
已开发出一种计算机模拟程序，以辅助临床化学统计质量控制程序的设计。这个“质量控制模拟器”允许用户研究分析程序中的参数（方法标准差、方差成分、数据舍入）以及控制程序中的参数（统计方法的选择、控制限、决策标准、控制观察次数）的影响。所研究的控制程序的性能通过其在几个不同水平的随机和系统误差下的拒收概率来表征，并以统计功效与分析误差大小的关系图呈现。可以根据这些性能特征比较不同控制程序的相对性能。该程序的另一个重要应用是设计控制程序，以确保在常规实验室分析中达到指定的分析质量水平。在两个典型的示例运行中展示了这个交互式模拟工具的实用性。
