Fotherby K, Akpoviroro J, Abdel-Rahman H A, Toppozada H K, de Souza J C, Coutinho E M, Koetsawang S, Nukulkarn P, Sheth U K, Mapa M K, Gopalan S, Plunkett E R, Brenner P F, Hickey M V, Grech E S, Lichtenberg R, Gual C, Molina R, Gomez-Rogers C, Kwon E, Kim S W, Chan T, Ratnam S S, Landgren B M, Shearman R P, Goldzieher J W, Dozier T S
Contraception. 1981 May;23(5):487-96. doi: 10.1016/0010-7824(81)90076-7.
The pharmacokinetics of a dose of 50 microgram ethynyloestradiol administered orally was studied in fourteen centres. Absorption was rapid and the highest serum concentrations of total ethynyloestradiol were found in most subjects at 1 h and by 24 h concentrations were less than 250 pg/ml. Calculation of the half-lives for absorption, distribution and elimination showed wide variations between subjects, the half-life of elimination varying from 2.5 h to more than 30 h. Bioavailability as measured by the area under the serum ethynyloestradiol concentration-time curve also showed more than a ten-fold variation. Intra-centre differences in the various parameters measured were as large as the inter-centre differences.
在14个中心研究了口服50微克乙炔雌二醇剂量的药代动力学。吸收迅速，大多数受试者在1小时时总乙炔雌二醇的血清浓度最高，到24小时时浓度低于250 pg/ml。吸收、分布和消除半衰期的计算显示受试者之间差异很大，消除半衰期从2.5小时到超过30小时不等。通过血清乙炔雌二醇浓度-时间曲线下面积测量的生物利用度也显示出超过10倍的差异。各中心测量的各种参数的中心内差异与中心间差异一样大。
