Reich E W, Cox R P, Becker M H, Genieser N B, McCarthy J G, Converse J M
Birth Defects Orig Artic Ser. 1978;14(6B):139-60.
Three patients are reported, two of whom had mothers who revealed ingestion of abortifacient drugs during pregnancy. All patients resemble one another and those described earlier with malformations that were probably either aminopterin- or methotrexate-induced. It is likely that Patients I and II have abnormalities associated with the teratogenic action of these folic-acid antagonists. The etiology of Patient III's defects remains uncertain.
报告了三名患者，其中两名患者的母亲在孕期曾透露服用过堕胎药。所有患者彼此相似，且与之前所描述的因氨甲蝶呤或甲氨蝶呤导致畸形的患者类似。患者I和患者II可能存在与这些叶酸拮抗剂致畸作用相关的异常情况。患者III缺陷的病因仍不确定。
