Gumbinger H G, Winterhoff H, Sourgens H, Kemper F H, Wylde R
Contraception. 1981 Jun;23(6):661-6. doi: 10.1016/s0010-7824(81)80008-x.
The antigonadotropic activity of Lithospermum and Lycopus species can be attributed to their phenolic components. These compounds represent precursors of biologically active products which are formed by an oxidation step. Complexity and instability of these products aggravates the elucidation of detailed structural properties. Therefore, the type of reaction involved had to be clarified. Among the oxidation products of phenolic substances, the corresponding quinones are found. It can be demonstrated that the reaction between quinones and unoxidized diphenols yields products with strong antigonadotropic activity. This type of reaction - the formation of quinhydrones - is proposed to be engaged in the formation of various products with antigonadotropic activity.
紫草属和地笋属植物的抗促性腺活性可归因于其酚类成分。这些化合物是生物活性产物的前体，通过氧化步骤形成。这些产物的复杂性和不稳定性加剧了对其详细结构性质的阐明。因此，必须弄清楚所涉及的反应类型。在酚类物质的氧化产物中，发现了相应的醌。可以证明，醌与未氧化的二酚之间的反应产生具有强抗促性腺活性的产物。这种反应类型——醌氢醌的形成——被认为参与了各种具有抗促性腺活性的产物的形成。
