Zhakhova Z N, Tripol'skaia N A
Biull Eksp Biol Med. 1978 Dec;86(12):684-7.
The heart was studied on the 11th, 12th, 14th, 16th and 18th days of the rabbit embryo development under normal conditions and in decreased uteroplacental circulation. Under normal conditions the heart weight/embryo weight ratio was particularly high during the intensive development of hemodynamic functional "embryo -- placenta -- uterus" system (on the 12th and the 14th day), and then this ratio decreased. An increase of the total heart nitrogen and alterations in fractional composition on account of increase of contractile proteins and stroma proteins was particularly high by the 18th day. In pathology a decrease of the embryo and heart weights was noted in the course of all the days of the experiment. By the 18th day the heart/embryo weight ratio suggested the beginning of spontaneous rehabilitation due to gradual increase of the uteroplacental circulation. However, the total nitrogen in the heart in all the test groups remained the same as in control or increased, this pointing to the heart dehydration. Changes in the fractional composition of the heart proteins indicated deep biochemical disorders in it, and this could serve as one of the causes of the heart functional derangement.
在正常条件下以及子宫胎盘循环减少的情况下，对兔胚胎发育第11、12、14、16和18天的心脏进行了研究。在正常条件下，当血流动力学功能“胚胎 - 胎盘 - 子宫”系统处于密集发育阶段时（第12天和第14天），心脏重量与胚胎重量之比特别高，然后该比例下降。到第18天时，由于收缩蛋白和基质蛋白增加，心脏总氮增加以及各部分组成发生变化的情况尤为明显。在病理学方面，在实验的所有天数中均观察到胚胎和心脏重量下降。到第18天时，心脏与胚胎重量之比表明由于子宫胎盘循环逐渐增加，自发恢复开始。然而，所有测试组心脏中的总氮量与对照组相同或增加，这表明心脏脱水。心脏蛋白质各部分组成的变化表明其存在深度生化紊乱，这可能是心脏功能紊乱的原因之一。
