Effects of haloperidol, methylergometrine and phentolamine on the frog ERG.

The effects of 3 x 10(--5) solutions of haloperidol (HAL), methylergometrine (ME) and phentolamine (PHA) in a dose of 27 microliters on the ERG of isolated frog eye cup preparations were examined. HAL induced a decrease in the amplitude of both the b- and d-waves which began about 20 min after the application. The dominating ME effect was a fast increase of the b-wave amplitude, while PHA did not induce any significant influences on the ERG.