Watanabe H, Menzies J A, Loo J C
Experientia. 1981;37(8):883-4. doi: 10.1007/BF01985693.
Isonicotinic acid hydrazide (isoniazid) was shown to react readily with 17 alpha-ethinyl-17 beta-hydroxyestr-4-en-3-one (norethindrone) to form the isonicotinyl hydrazone of the steroid under conditions likely to exist in the stomach. The hydrazone was detected in guinea-pig, but not rat, plasma following its oral administration. Rat liver tissue metabolized the compound more rapidly than guinea-pig liver in vitro which probably accounts for the failure to detect the hydrazone in rat plasma.
异烟肼被证明在胃中可能存在的条件下能与17α-乙炔基-17β-羟基雌甾-4-烯-3-酮（炔诺酮）迅速反应，形成该甾体的异烟酰腙。口服给药后，在豚鼠血浆中检测到了该腙，但在大鼠血浆中未检测到。在体外，大鼠肝脏组织比豚鼠肝脏更快地代谢该化合物，这可能是在大鼠血浆中未能检测到该腙的原因。
