Salakhova N S, Mirmakhmudova S I, Gainutdinov M Kh, Turakulov Ia Kh
Biull Eksp Biol Med. 1978 Dec;86(12):721-3.
Development of rabbit fetal tissues sensitivity to thyroxin was studied on the basis of changes in alpha-glycerophosphate oxidase activity in the liver mitochondria of pregnant rabbits and their fetuses to which thyroxin was administered at different stages of pregnancy. T4 administration up to the 23rd day of gestation caused an increase in the enzyme activity in the maternal liver mitochondria only, whereas in the fetus it was at the control level. From the 24th day of pregnancy an increase of the alpha-glycerophosphate oxidase activity was seen in the fetal liver mitochondria. This can be explained by the appearance of rabbit fetal tissues sensitivity to maternal thyroxin at this period of gestation, increasing by the end of pregnancy.
基于在妊娠不同阶段给怀孕兔子及其胎儿注射甲状腺素后，对其肝脏线粒体中α-磷酸甘油氧化酶活性变化的研究，探讨了兔胎儿组织对甲状腺素敏感性的发育情况。在妊娠第23天之前给予甲状腺素（T4），仅导致母体肝脏线粒体中的酶活性增加，而胎儿肝脏线粒体中的酶活性处于对照水平。从妊娠第24天起，胎儿肝脏线粒体中的α-磷酸甘油氧化酶活性增加。这可以解释为在此妊娠阶段兔胎儿组织对母体甲状腺素的敏感性出现，在妊娠末期这种敏感性增加。
