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[去甲肾上腺素和血管紧张素II对脑和肾血液供应以及全身动脉压变化的影响]

[Effect of noradrenaline and angiotensin II on the brain and kidney blood supply with changes in systemic arterial pressure].

作者信息

Beketov A I, Korneliuk I K

出版信息

Farmakol Toksikol. 1981 Jul-Aug;44(4):414-7.

PMID:7286196
Abstract

Hydrogen clearance was used in experiments on anesthetized cats to demonstrate that intravenous infusions of noradrenaline induced an increase in cerebral blood supply and reduction of renal blood flow both in anesthetized animals and in the presence of hypotension. In these conditions, angiotensin II lowered the cerebral and renal blood flow. Hypotension enhanced the reactions of the cerebral and renal blood flow to the action of vasopressor agents. The intensity of the reactions was consistent with the degree of vascular autocontrol preservation in the brain and kidneys.

摘要

在对麻醉猫进行的实验中,采用氢清除法来证明,静脉输注去甲肾上腺素会使麻醉动物以及处于低血压状态下的动物脑血流量增加,肾血流量减少。在这些情况下,血管紧张素II会降低脑血流量和肾血流量。低血压会增强脑血流量和肾血流量对血管升压药作用的反应。这些反应的强度与脑和肾中血管自身调节的保留程度一致。

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