一种关于能量代谢在肿瘤细胞生长中作用的遗传学方法：糖酵解或呼吸作用缺陷的成纤维细胞突变体的致瘤性。 - Suppr

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超能文献

A genetic approach to the role of energy metabolism in the growth of tumor cells: tumorigenicity of fibroblast mutants deficient either in glycolysis or in respiration.

作者信息

Franchi A, Silvestre P, Pouysségur J

出版信息

Int J Cancer. 1981 Jun 15;27(6):819-27. doi: 10.1002/ijc.2910270614.

DOI:10.1002/ijc.2910270614

PMID:7287229

Abstract

摘要

相似文献

A genetic approach to the role of energy metabolism in the growth of tumor cells: tumorigenicity of fibroblast mutants deficient either in glycolysis or in respiration.一种关于能量代谢在肿瘤细胞生长中作用的遗传学方法：糖酵解或呼吸作用缺陷的成纤维细胞突变体的致瘤性。

Int J Cancer. 1981 Jun 15;27(6):819-27. doi: 10.1002/ijc.2910270614.

Emergence of hamster fibroblast tumors in nude mice--evidence for in vivo selection leading to loss of growth factor requirement.裸鼠中仓鼠成纤维细胞瘤的出现——体内选择导致生长因子需求丧失的证据。

J Cell Physiol. 1981 Dec;109(3):387-96. doi: 10.1002/jcp.1041090303.

Multistep origin of tumor-forming ability in Chinese hamster embryo fibroblast cells.中国仓鼠胚胎成纤维细胞中肿瘤形成能力的多步骤起源

Cancer Res. 1982 Feb;42(2):389-96.

Isolation of a Chinese hamster fibroblast mutant defective in hexose transport and aerobic glycolysis: its use to dissect the malignant phenotype.分离出一种在己糖转运和有氧糖酵解方面存在缺陷的中国仓鼠成纤维细胞突变体：利用其剖析恶性表型。

Proc Natl Acad Sci U S A. 1980 May;77(5):2698-701. doi: 10.1073/pnas.77.5.2698.

Tumorigenicity of CHO glycosylation mutants in the nude mouse.

Rev Fr Transfus Immunohematol. 1986 Sep;29(4):223-32. doi: 10.1016/s0338-4535(86)80017-4.

Hyperthermia-induced cell death, thermotolerance, and heat shock proteins in normal, respiration-deficient, and glycolysis-deficient Chinese hamster cells.

Cancer Res. 1986 Jan;46(1):324-7.

Genetic analysis of tumorigenesis: X. Chromosome studies of transformed mutants and tumor-derived CHEF/18 cells.肿瘤发生的遗传分析：X. 转化突变体和肿瘤来源的CHEF/18细胞的染色体研究

Somatic Cell Genet. 1982 Sep;8(5):677-89. doi: 10.1007/BF01542860.

In vivo pH in metabolic-defective Ras-transformed fibroblast tumors: key role of the monocarboxylate transporter, MCT4, for inducing an alkaline intracellular pH.代谢缺陷型 Ras 转化成纤维细胞瘤中的体内 pH 值：单羧酸转运蛋白 MCT4 对于诱导碱性细胞内 pH 值的关键作用。

Int J Cancer. 2012 Apr 1;130(7):1511-20. doi: 10.1002/ijc.26125. Epub 2011 May 30.

Differential tumorigenicity of growth factor-dependent versus -independent CCL39 lung fibroblast lines in nude mice.生长因子依赖性与非依赖性CCL39肺成纤维细胞系在裸鼠中的肿瘤发生差异性

J Natl Cancer Inst. 1986 Jul;77(1):105-14.

Cell mutants as a tool to study malignant transformation of fibroblasts.细胞突变体作为研究成纤维细胞恶性转化的工具。

Prog Clin Biol Res. 1980;41:931-44.

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AMP-activated protein kinase is dispensable for maintaining ATP levels and for survival following inhibition of glycolysis, but promotes tumour engraftment of Ras-transformed fibroblasts.AMP激活的蛋白激酶对于维持ATP水平以及糖酵解抑制后的存活并非必需，但可促进Ras转化的成纤维细胞的肿瘤移植。

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Glycogen Synthesis is Induced in Hypoxia by the Hypoxia-Inducible Factor and Promotes Cancer Cell Survival.缺氧诱导因子诱导缺氧时的糖原合成并促进癌细胞存活。

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CD147 subunit of lactate/H+ symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors.乳酸/H+协同转运蛋白 MCT1 和缺氧诱导的 MCT4 的 CD147 亚基对于糖酵解肿瘤的能量代谢和生长至关重要。

Proc Natl Acad Sci U S A. 2011 Oct 4;108(40):16663-8. doi: 10.1073/pnas.1106123108. Epub 2011 Sep 19.

Tumour hypoxia induces a metabolic shift causing acidosis: a common feature in cancer.肿瘤缺氧会引起代谢转变导致酸中毒：这是癌症的一个共同特征。

J Cell Mol Med. 2010 Apr;14(4):771-94. doi: 10.1111/j.1582-4934.2009.00994.x. Epub 2009 Dec 8.

Down-regulation of the hexose transport system: metabolic basis studied with a fibroblast mutant lacking phosphoglucose isomerase.己糖转运系统的下调：利用缺乏磷酸葡萄糖异构酶的成纤维细胞突变体进行的代谢基础研究

Proc Natl Acad Sci U S A. 1982 Jun;79(12):3777-9. doi: 10.1073/pnas.79.12.3777.

Further clues concerning the vectors essential to regulation of hexose transport, as studied in fibroblast cultures from a metabolic mutant.在对一种代谢突变体的成纤维细胞培养物进行研究时，发现了有关调节己糖转运所必需载体的更多线索。

Proc Natl Acad Sci U S A. 1984 Feb;81(4):1126-9. doi: 10.1073/pnas.81.4.1126.

Mutations in the phosphoglucose isomerase gene can lead to marked alterations in cellular ATP levels in cultured fibroblasts exposed to simple nutrient shifts.磷酸葡萄糖异构酶基因突变可导致暴露于简单营养变化的培养成纤维细胞中细胞ATP水平发生显著改变。

Proc Natl Acad Sci U S A. 1985 May;82(9):2761-3. doi: 10.1073/pnas.82.9.2761.

Hexose transport control in a fibroblast metabolic mutant can be promoted more effectively by D-allose than by glucose.在一种成纤维细胞代谢突变体中，D-阿洛糖比葡萄糖能更有效地促进己糖转运控制。

Proc Natl Acad Sci U S A. 1986 Aug;83(16):5858-60. doi: 10.1073/pnas.83.16.5858.

Concerted hexose transport curb by tunicamycin is rendered irreversible by glucose or allose in medium containing L-glutamine.在含有L-谷氨酰胺的培养基中，衣霉素对己糖转运的协同抑制作用会被葡萄糖或阿洛糖转变为不可逆的。

Proc Natl Acad Sci U S A. 1989 Jun;86(12):4350-1. doi: 10.1073/pnas.86.12.4350.

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