Taylor-Robinson D
Isr J Med Sci. 1981 Jul;17(7):616-21.
Naturally occurring mycoplasmal arthritis in various animals species and the ability to induce mycoplasmal arthritis experimentally have been the main reasons for searching for evidence of mycoplasmal infection in the joints of patients with rheumatoid arthritis. However, reliable reports of the isolation of mycoplasmas from synovial fluids and tissue of such patients do not exist, and measurements of specific antibodies have not proved rewarding. There is some evidence that infection by Mycoplasma pneumoniae occasionally has an arthritic sequela, although the microorganism has not been isolated from the joints of immunocompetent patients. In contrast, this and other mycoplasmas, including ureaplasmas, have been isolated from the arthritic joints of several hypogammaglobulinemic patients, and there is some evidence to indicate that the organisms are responsible for the disease. A relationship between mycoplasmas and sexually acquired Reiter's disease is unproven, but deserves thorough investigation in view of the link between ureaplasmas and nongonococcal urethritis. Furthermore, as new media and techniques become available, the possibility the mycoplasmas may have some role in rheumatoid arthritis should be reappraised.
各种动物物种中自然发生的支原体关节炎以及通过实验诱导支原体关节炎的能力，一直是在类风湿性关节炎患者关节中寻找支原体感染证据的主要原因。然而，目前尚无关于从此类患者的滑液和组织中分离出支原体的可靠报告，而且对特异性抗体的检测也未取得有价值的结果。有一些证据表明，肺炎支原体感染偶尔会有关节炎后遗症，尽管在免疫功能正常的患者关节中尚未分离出该微生物。相比之下，包括脲原体在内的这种及其他支原体已从数名低丙种球蛋白血症患者的关节炎关节中分离出来，并且有一些证据表明这些微生物与该疾病有关。支原体与性传播的赖特综合征之间的关系尚未得到证实，但鉴于脲原体与非淋菌性尿道炎之间的联系，值得进行深入研究。此外，随着新的培养基和技术的出现，应重新评估支原体可能在类风湿性关节炎中发挥某种作用的可能性。
