大鼠近交系（褐家鼠）中的胆固醇反应。

Cholesterol response in inbred strains of rats, Rattus norvegicus.

作者信息

Van Zutphen L F, Den Bieman M G

出版信息

J Nutr. 1981 Oct;111(10):1833-8. doi: 10.1093/jn/111.10.1833.

DOI:10.1093/jn/111.10.1833

Abstract

A hypercholesterolemic diet fed to rats revealed significant interstrain differences in plasma cholesterol levels. Hyperresponding and hyporesponding strains could be distinguished from normoresponding strains within 3 weeks. The increase in plasma cholesterol level was more than 300 mg/100 ml in the hyperresponding strains BN/Cpb, SD/Cpb and WE/Z and less than 50 mg/100 ml in the hyporesponding strains S3/Cpb and SHR/Cpb. These differences were primarily genetically determined: the calculated coefficient of genetic determination (g2) of the response was 0.84. The response is not correlated with variation in plasma esterase or alkaline phosphatase isozyme patterns.

摘要

给大鼠喂食高胆固醇饮食后，发现不同品系大鼠的血浆胆固醇水平存在显著差异。在3周内，高反应品系和低反应品系可与正常反应品系区分开来。高反应品系BN/Cpb、SD/Cpb和WE/Z的血浆胆固醇水平升高超过300mg/100ml，而低反应品系S3/Cpb和SHR/Cpb的升高则低于50mg/100ml。这些差异主要由基因决定：反应的计算遗传决定系数（g2）为0.84。该反应与血浆酯酶或碱性磷酸酶同工酶模式的变化无关。