哺乳期、缺钙及氟摄入对大鼠骨转换的影响：骨吸收与形成的同位素测量

Effect of lactation and calcium deficiency, and of fluoride intake, on bone turnover in rats: isotopic measurements of bone resorption and formation.

作者信息

Wong K M, Singer L, Ophaug R H, Klein L

出版信息

J Nutr. 1981 Oct;111(10):1848-54. doi: 10.1093/jn/111.10.1848.

DOI:10.1093/jn/111.10.1848

Abstract

The rates of bone formation and resorption were investigated, using isotopic measurements, in calcium-deficient lactating rats and compared to those of calcium-sufficient non-lactating animals. Bone formation was measured by 3H-proline uptake and 3H-hydroxyproline formation, and resorption was measured by the loss of previously incorporated 3H-tetracycline, in whole humerus. The effect of 50 ppm fluoride in the drinking water on both parameters was also examined. The stress of lactation and calcium deficiency significantly increased the rates of bone resorption and formation, but the increase in resorption was greater than in formation which resulted in a net decrease in bone mineral and matrix. Fluoride had no effect on various parameters measured.

摘要

采用同位素测量法，对缺钙的泌乳大鼠的骨形成和吸收速率进行了研究，并与钙充足的非泌乳动物进行了比较。通过全肱骨对3H-脯氨酸的摄取和3H-羟脯氨酸的形成来测量骨形成，通过先前掺入的3H-四环素的流失来测量骨吸收。还研究了饮用水中50 ppm氟化物对这两个参数的影响。泌乳和缺钙应激显著增加了骨吸收和形成的速率，但吸收的增加大于形成的增加，导致骨矿物质和基质净减少。氟化物对所测的各项参数均无影响。