放射免疫分析法与薄层色谱分析法用于估算血浆泼尼松龙浓度的比较。

Comparison of radioimmunoassay and thin layer chromatographic assay methods for estimation of plasma prednisolone concentrations.

作者信息

Al-Habet S M, McAllister W A, Collins J V, Rogers H J

出版信息

J Pharmacol Methods. 1981 Sep;6(2):137-42. doi: 10.1016/0160-5402(81)90036-x.

Abstract

Radioimmunoassay and thin layer chromatographic methods of assay for prednisolone in plasma have been compared. These methods are comparable in terms of ease, speed of execution, and cost. They yielded similar estimates of prednisolone concentration without important bias over the concentration range generally encountered in clinical practice and may be considered comparable for pharmacokinetic studies.

摘要

对血浆中泼尼松龙的放射免疫测定法和薄层色谱测定法进行了比较。这些方法在操作简便性、执行速度和成本方面具有可比性。在临床实践中通常遇到的浓度范围内，它们对泼尼松龙浓度的估计相似，且无重要偏差，可认为在药代动力学研究中具有可比性。