一种泼尼松龙的放射免疫分析方法：与竞争性蛋白结合法的比较。
A radioimmunoassay method for prednisolone: comparison with the competitive protein binding method.
作者信息
Chakraborty J, English J, Marks V, Dumasia M C, Chapman D J
出版信息
Br J Clin Pharmacol. 1976 Oct;3(5):903-6. doi: 10.1111/j.1365-2125.1976.tb00645.x.
Abstract
Cross reactivity of prednisolone with an antiserum raised against dexamethasone-21-hemisuccinate conjugated with bovine serum albumin was utilized to develop a radioimmunoassay for prednisolone in unextracted plasma. The results are in good agreement with those obtained with a standard competitive protein binding method employing prior extraction and separation of the synthetic from endogenous steroids.
摘要
利用泼尼松龙与针对与牛血清白蛋白偶联的地塞米松-21-半琥珀酸酯产生的抗血清之间的交叉反应，开发了一种用于未提取血浆中泼尼松龙的放射免疫测定法。结果与采用合成类固醇与内源性类固醇的预先提取和分离的标准竞争性蛋白质结合方法所获得的结果高度一致。
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本文引用的文献
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J Clin Endocrinol Metab. 1974 Mar;38(3):407-12. doi: 10.1210/jcem-38-3-407.
2
Single-antibody technique for radioimmunoassay of cortisol in unextracted serum or plasma.用于未提取血清或血浆中皮质醇放射免疫测定的单抗体技术。
Clin Chem. 1974 Mar;20(3):365-8.
3
Production and properties of antisera to dexamethasone-protein conjugates.地塞米松 - 蛋白质偶联物抗血清的制备及其性质
Biochem J. 1973 Jun;133(2):401-4. doi: 10.1042/bj1330401.
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Radioimmunoassay for prednisolone.
Steroids. 1973 Jun;21(6):833-46. doi: 10.1016/0039-128x(73)90124-4.
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Corticosteroids in liver disease: studies on the biological conversion of prednisone to prednisolone and plasma protein binding.肝脏疾病中的皮质类固醇：关于泼尼松向泼尼松龙的生物转化及血浆蛋白结合的研究
Gut. 1972 Sep;13(9):690-6. doi: 10.1136/gut.13.9.690.
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Patterns of plasma levels of prednisolone after oral administration in man.人口服泼尼松龙后血浆水平的模式。
J Pharmacokinet Biopharm. 1974 Apr;2(2):175-87. doi: 10.1007/BF01061507.
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