慢性破伤风：肌肉的临床报告及组织化学分析

Chronic tetanus: clinical report and histochemistry of muscle.

作者信息

Risk W S, Bosch E P, Kimura J, Cancilla P A, Fischbeck K H, Layzer R B

出版信息

Muscle Nerve. 1981 Sep-Oct;4(5):363-6. doi: 10.1002/mus.880040502.

Abstract

A patient who was partially immune to tetanus developed nonfulminant tetanus after a minor injury. Manifestations of the disease persisted for over 17 months. Electrophysiologic studies revealed an absent silent period in the masseter muscle, large-amplitude F-responses, and denervation. A muscle biopsy showed neurogenic atrophy with reinnervation. This observation supports the existence of chronic tetanus and provides morphologic evidence for a peripheral action of tetanus toxin in humans.

摘要

一名对破伤风有部分免疫力的患者在受轻伤后发生了非暴发性破伤风。该病的症状持续了17个多月。电生理研究显示咬肌无静息期、F波反应幅度大以及失神经支配。肌肉活检显示神经源性萎缩伴神经再支配。这一观察结果支持慢性破伤风的存在，并为破伤风毒素在人体中的外周作用提供了形态学证据。