Niepokojczycka E, Szumiel I, Walicka M
Neoplasma. 1981;28(4):435-40.
Misonizadole exerts an equal cytotoxic effect on L5178Y-R and L5178Y-S cells; 5 mM misonidazole sensitizes cells of both strains to a similar extent under hypoxic conditions: the effect of drug in 59% of the oxygen effect in L5178Y-R cells and 52% in L5178Y-S cells. It was previously reported that the amount of initial DNA damage determined by the alkaline unwinding technique is 1.3 times lower in irradiated hypoxic L5178Y-R cells than in L5178Y-S cells. Hence it seems that the drug ability to sensitize these cell strains does not depend on amount of initial DNA damage available for interaction. Although the examined L5178Y strains differ in radiosensitivity, their ability to repair oxygen and misonidazole-dependent cellular damage is similar.
米索硝唑对L5178Y - R和L5178Y - S细胞具有同等的细胞毒性作用；5 mM米索硝唑在缺氧条件下使两种细胞株的细胞敏感程度相似：该药物对L5178Y - R细胞的作用为氧效应的59%，对L5178Y - S细胞的作用为氧效应的52%。此前有报道称，通过碱性解旋技术测定，照射后的缺氧L5178Y - R细胞中的初始DNA损伤量比L5178Y - S细胞低1.3倍。因此，似乎该药物使这些细胞株敏感的能力并不取决于可用于相互作用的初始DNA损伤量。尽管所检测的L5178Y细胞株在放射敏感性方面存在差异，但它们修复氧和米索硝唑依赖性细胞损伤的能力相似。
