Uphouse L, Russell M
Neurobehav Toxicol Teratol. 1981 Fall;3(3):281-4.
The effects of in vivo exposure to acrylamide on 3H-spiroperidol binding to striatal and (3)5-HT binding to forebrain membranes were investigated. Rats were gavaged with 100 mg/kg acrylamide and sacrificed at various times thereafter. Rapid changes were seen with specific binding of spiroperidol increasing by 1/2 hour and 5-HT binding by 2 hours after acrylamide treatment. Although the overall effect of acrylamide was to elevate binding for at least 24 hours, binding of spiroperidol may have exhibited a biphasic profile. The possibility of dual time-dependent mechanisms involved in the effects of acrylamide is discussed.
研究了体内暴露于丙烯酰胺对3H-螺哌啶醇与纹状体结合以及5-羟色胺与前脑细胞膜结合的影响。给大鼠灌胃100mg/kg丙烯酰胺，此后在不同时间处死。丙烯酰胺处理后半小时，螺哌啶醇的特异性结合迅速增加，2小时后5-羟色胺结合增加。虽然丙烯酰胺的总体作用是使结合至少升高24小时，但螺哌啶醇的结合可能呈现双相曲线。文中讨论了丙烯酰胺作用涉及双重时间依赖性机制的可能性。
