Vorhees C V
Neurobehav Toxicol Teratol. 1981 Fall;3(3):295-301.
Pregnant Sprague-Dawley rats were daily administered either 20 mg/kg or naloxone HCl in saline or saline alone IP in two divided doses on days 7-20 of gestation (i.e., 40 mg/kg/day of naloxone). The offspring were reared by their biological dams and were examined for physical, neurological and behavioral development using a battery of psychoteratogenic tests administered from postnatal day 3 to adulthood (120 days of age). The Naloxone offspring were accelerated in postweaning growth, upper incisor eruption, righting development, startle development, home scent discrimination, and in directional swimming development, but as adults, showed impaired Biel water maze learning. The current data support the concept that early exposure of rats to naloxone can produce long-term changes in development and in adult behavioral performance.
在妊娠第7至20天，将怀孕的斯普拉格-道利大鼠每天腹腔注射两次，分别给予20毫克/千克盐酸纳洛酮的生理盐水溶液或仅给予生理盐水（即每天40毫克/千克纳洛酮）。后代由其生母抚养，并在出生后第3天至成年期（120日龄）通过一系列精神致畸试验检查其身体、神经和行为发育情况。纳洛酮组的后代在断奶后生长、上门齿萌出、翻正反射发育、惊跳反射发育、辨别家的气味以及定向游泳发育方面加速，但成年后在比埃尔水迷宫学习方面表现受损。目前的数据支持这样的概念，即大鼠早期接触纳洛酮会在发育和成年行为表现方面产生长期变化。
