Milar K S, Krigman M R, Grant L D
Neurobehav Toxicol Teratol. 1981 Fall;3(3):369-73.
Five groups of rats exposed to varying doses of lead by gastric intubation from Day 3 to Day 30 of life were tested to determine whether lead affects memory. A variable intertrial interval spatial alternation task was used to examine memory; it permits generation of a complete retention curve within subjects in a single session. Because of lead's putative effects on the cholinergic neuronal system, the cholinergic drugs controls to the drugs and to compare drug effects with lead effects. Orderly memory functions were obtained in all animals; however lead-exposed groups did not differ in performance from controls. Scoopolamine decreased alternation accuracy but its effects did not differ across the neonatal dose groups.
从出生后第3天到第30天，对五组经胃插管给予不同剂量铅的大鼠进行测试，以确定铅是否会影响记忆。采用可变试验间隔空间交替任务来检测记忆；该任务能够在单次实验中在个体内生成完整的记忆保持曲线。鉴于铅对胆碱能神经元系统的假定作用，使用胆碱能药物作为对照，以比较药物效应与铅的效应。所有动物均获得了有序的记忆功能；然而，铅暴露组在行为表现上与对照组并无差异。东莨菪碱降低了交替准确性，但其效应在新生剂量组之间并无差异。
