某些胆碱能药物对大鼠条件性跳杆反应的影响。

Effect of some cholinergic drugs on the conditioned pole jump response in rats.

作者信息

Bhargava V K, Pushpavati C P

出版信息

Pharmacol Biochem Behav. 1981 Oct;15(4):537-8. doi: 10.1016/0091-3057(81)90203-3.

Abstract

Rats were trained to pole jump to a buzzer as the conditioned response. Cholinergic agents, oxotremorine and physostigmine significantly depressed this response. The effect was blocked by atropine. Nicotine and carbachol failed to modify the conditioned pole jump response. It is suggested that the central muscarinic inhibitory receptors are involved in the action of these drugs.

摘要

训练大鼠以听到蜂鸣声后进行跳杆作为条件反应。胆碱能药物氧化震颤素和毒扁豆碱显著抑制了这种反应。该效应被阿托品阻断。尼古丁和卡巴胆碱未能改变条件性跳杆反应。提示中枢毒蕈碱抑制性受体参与了这些药物的作用。