Zeide M S, Wiesel S, Terry R, Stein D
Clin Orthop Relat Res. 1978 Jul-Aug(134):290-2.
A syndrome that resembles Systemic Lupus Erythematosus both clinically and on laboratory studies may be induced by procainamide. It is associated with multisystemic involvement, positive Antinuclear Antibody titers (ANA), and positive LE cell preparations. In patients on procainamide therapy the syndrome must be differentiated from osteoarthritis, myocardial infarction, and pulmonary embolism. When procainamide is discontinued, this Lupus-like syndrome is usually reversible. Other drugs, including hydralazine and isoniazid have also been implicated in provoking this Lupus-like syndrome.
普鲁卡因胺可能引发一种在临床和实验室检查上都类似于系统性红斑狼疮的综合征。它与多系统受累、抗核抗体滴度（ANA）阳性以及狼疮细胞检查阳性有关。对于接受普鲁卡因胺治疗的患者，必须将该综合征与骨关节炎、心肌梗死和肺栓塞相鉴别。停用普鲁卡因胺后，这种类狼疮综合征通常是可逆的。其他药物，包括肼屈嗪和异烟肼，也被认为与引发这种类狼疮综合征有关。
