Kohn R, Nofsinger K, Freedman S I
Am J Ophthalmol. 1981 Sep;92(3):363-7. doi: 10.1016/0002-9394(81)90525-0.
We treated a 76-year-old man who had an epithelial carcinoma that involved the canaliculus and extended into the lacrimal sac. Despite what appeared to be adequate resection (the surgical margins were completely free of tumor on both frozen and paraffin section), the tumor recurred less than one month later. The patient underwent wide local incision, including en bloc removal of the medial third of both eyelids and inner canthi, canaliculi, lacrimal sac, and nasolacrimal duct, and resection of the anterior lacrimal crest, lacrimal bone, anterior portion of the ethmoid bone, anterior medial wall of the maxilla, and subjacent periosteum and mucous membranes. Sixteen months later, the tumor has not recurred. This infiltrating papillary squamous cell carcinoma histologically demonstrated the most rapid and destructive recurrence of any such tumor originating in the lacrimal system.
我们提供我们治疗了一名76岁男性,其患有累及泪小管并延伸至泪囊的上皮癌。尽管看似切除充分(冰冻切片和石蜡切片的手术切缘均未见肿瘤),但肿瘤在不到1个月后复发。患者接受了广泛的局部切口手术,包括整块切除双侧眼睑内侧三分之一、内眦、泪小管、泪囊和鼻泪管,切除泪前嵴、泪骨、筛骨前部、上颌骨前内侧壁以及下方的骨膜和黏膜。16个月后,肿瘤未复发。这种浸润性乳头状鳞状细胞癌在组织学上显示出泪腺系统起源的此类肿瘤中最迅速且具有破坏性的复发。