Monnier L, Pham T C, Aguirre L, Orsetti A, Mirouze J
Diabetes Care. 1978 Mar-Apr;1(2):83-8. doi: 10.2337/diacare.1.2.83.
In eight patients exhibiting chemical diabetes mellitus with a poststimulative hypoglycemia, we observed that the pattern of the oral glucose tolerance test (OGTT) was improved when indigestible fiber was added to the oral glucose load. As compared with a standard OGTT, the peak blood glucose, expressed as per cent change from baseline, was particularly blunted by pectin or by cellulose phosphate but remained unchanged with cellulose supplementation. The time interval required to reach the blood glucose peak was significantly prolonged with pectin. The rate of blood glucose rise was reduced to a greater extent by pectin than by cellulose phosphate, which in turn was more efficient than cellulose. The blood glucose nadir expressed as per cent change from baseline was blunted by pectin, while the results were not significantly different after addition of either cellulose phosphate or cellulose. On the other hand, the plasma immunoreactive insulin did not show any significant change whether the glucose was given with or without one of the aforementioned types of fiber. From these results, it is concluded that an additional fiber intake may be of interest in the management of chemical diabetes. The use of pectin may diminish the poststimulative hypoglycemia.
在8例表现为化学性糖尿病且刺激后出现低血糖的患者中，我们观察到，在口服葡萄糖负荷中添加不可消化纤维后，口服葡萄糖耐量试验（OGTT）的模式得到改善。与标准OGTT相比，以相对于基线的变化百分比表示的血糖峰值，被果胶或磷酸纤维素显著降低，但补充纤维素后保持不变。果胶使达到血糖峰值所需的时间间隔显著延长。果胶比磷酸纤维素更能降低血糖上升速率，而磷酸纤维素又比纤维素更有效。以相对于基线的变化百分比表示的血糖最低点被果胶降低，而添加磷酸纤维素或纤维素后结果无显著差异。另一方面，无论葡萄糖是否与上述类型的纤维之一一起给予，血浆免疫反应性胰岛素均未显示任何显著变化。从这些结果可以得出结论，额外摄入纤维可能对化学性糖尿病的管理有益。使用果胶可能会减轻刺激后的低血糖。
