Schwartz S E, Levine G D
Gastroenterology. 1980 Nov;79(5 Pt 1):833-6.
The effects of acute and chronic dietary fiber (cellulose and pectin) supplementation on both intestinal glucose absorption and oral glucose tolerance were studied in rats. The effect of intraluminal fiber on intestinal glucose absorption was evaluated in perfused jejunal loops as was the effect of a single cellulose or pectin-supplemented meal on serum glucose responses to a carbohydrate load. Neither pectin nor cellulose impaired jejunal glucose absorption, but pectin did decrease serum glucose responses to an oral carbohydrate load. Chronic fiber supplementation significantly decreased intestinal glucose absorption in rats who had received for 5 wk a fiber-free diet supplemented with either cellulose (10%) or pectin (5%). Chronic supplementation with cellulose or pectin impaired intestinal glucose absorption and decreased serum glucose responses. These results suggest that differences in glucose homeostasis observed after ingestion of single high-fiber meals may be caused by viscosity-related delays in the rate of gastric emptying, whereas differences noted after chronic supplementation of dietary fiber are related to adaptive changes in the intestine.
研究了急性和慢性补充膳食纤维（纤维素和果胶）对大鼠肠道葡萄糖吸收和口服葡萄糖耐量的影响。通过灌注空肠袢评估肠腔内纤维对肠道葡萄糖吸收的影响，以及单次补充纤维素或果胶的餐食对碳水化合物负荷后血清葡萄糖反应的影响。果胶和纤维素均未损害空肠葡萄糖吸收，但果胶确实降低了口服碳水化合物负荷后的血清葡萄糖反应。在接受了5周不含纤维饮食并补充了纤维素（10%）或果胶（5%）的大鼠中，长期补充纤维显著降低了肠道葡萄糖吸收。长期补充纤维素或果胶会损害肠道葡萄糖吸收并降低血清葡萄糖反应。这些结果表明，摄入单一高纤维餐食后观察到的葡萄糖稳态差异可能是由与粘度相关的胃排空速率延迟引起的，而长期补充膳食纤维后观察到的差异与肠道的适应性变化有关。
