Quednau D, Garbrecht M, Stolzenbach G, Nowakowski H
Dtsch Med Wochenschr. 1978 Dec 22;103(51):2029-32. doi: 10.1055/s-0028-1129390.
Rebound regression occurred in 13 of 42 females (30.9% with metastasising carcinoma of the breast in the postmenopausal period in whom additional hormonal treatment with ethinyl oestradiol had brought about a remission. Duration of the rebound response ranged from 3 to 44 months (average 11.2 months; mean 8 months). There was a significantly longer duration of remission (18.7 months compared with 12.0 months; P = 0.01) in patients with than those without a rebound response. There was also a significant correlation between the duration of the preceding remission under additional hormonal treatment and the duration of the subsequent rebound response (P less than 0.01). On the other hand, there was a negative but not significant correlation between the free interval duration which preceded the metastasisation and the duration of the rebound regression.
42名女性中有13名出现了反弹消退（30.9%），这些女性患有绝经后转移性乳腺癌，接受乙炔雌二醇的额外激素治疗后病情缓解。反弹反应的持续时间为3至44个月（平均11.2个月；中位数8个月）。有反弹反应的患者缓解期明显更长（18.7个月，而无反弹反应的患者为12.0个月；P = 0.01）。在额外激素治疗下之前缓解期的持续时间与随后反弹反应的持续时间之间也存在显著相关性（P < 0.01）。另一方面，转移前的无病间期持续时间与反弹消退的持续时间之间存在负相关，但不显著。
