Haase M, Schneider W
Dtsch Med Wochenschr. 1978 Dec 22;103(51):2033-6. doi: 10.1055/s-0028-1129391.
Twenty persons working in the institute testing rabies vaccines and sera were vaccinated three times at monthly intervals with HDC rabies vaccine. In 9 persons in whom the basic immunisation was completed more than two years previously a booster dose was given. The antibodies formed after vaccination were measured in international units (IU). Serum antibody levels rose constantly during the basic immunisation period. Four weeks after the second vaccination definite sero-conversion could be demonstrated in all persons, the mean antibody level was 6.05 IU/ml. The antibody level rose after the third vaccination to a mean of 10.7 IU/ml and sank over the following six months to 1.5 IU/ml. Two years later the mean level was 0.5 IU/ml. After boostering the antibody level rose to 29.6 IU/ml within a week and after two weeks reached one hundred fold the original level. In view of these results which agree with other studies reexamination of the present vaccination scheme for prophylactic rabies vaccination is recommended.
在该研究所从事狂犬病疫苗和血清检测工作的20人，每隔一个月用HDC狂犬病疫苗接种三次。在9名两年多前已完成基础免疫的人员中，给予了一剂加强针。接种后形成的抗体以国际单位（IU）进行测量。基础免疫期间血清抗体水平持续上升。第二次接种四周后，所有人均出现明确的血清转化，平均抗体水平为6.05 IU/ml。第三次接种后抗体水平升至平均10.7 IU/ml，并在接下来的六个月内降至1.5 IU/ml。两年后平均水平为0.5 IU/ml。加强免疫后，抗体水平在一周内升至29.6 IU/ml，两周后达到原来水平的100倍。鉴于这些与其他研究一致的结果，建议重新审视目前的预防性狂犬病疫苗接种方案。
