清醒家兔的颈动脉窦-血压反射：心输出量和外周阻力变化的相对重要性。

The carotid sinus-blood pressure reflex in conscious rabbits: the relative importance of changes in cardiac output and peripheral resistance.

作者信息

Faris I B, Jamieson G G, Ludbrook J

出版信息

Aust J Exp Biol Med Sci. 1981 Jun;59(Pt 3):335-41. doi: 10.1038/icb.1981.27.

DOI:10.1038/icb.1981.27

Abstract

This paper reports experiments to determine the relative roles of changes in cardiac output and systemic vascular resistance in determining the blood pressure response to intermittent step-changes and continuous sinusoidal changes in carotid sinus transmural pressure. Conscious rabbits with a variable-pressure capsule implanted around an innervated carotid sinus were used. After step-change in capsule pressure the approximate proportions of the changes in blood pressure attributable to changes in cardiac output were, during the pressor response, 7% after 2.5 s, 22% after 10 s and 27% at plateau, and during the depressor response 100%, 8% and 17%, respectively. During sinusoidal change in capsule pressure a mean 7% of the change in blood pressure over the full cycle was attributable to change in cardiac output.

摘要

本文报告了一些实验，旨在确定心输出量变化和全身血管阻力在决定血压对颈动脉窦跨壁压间歇性阶跃变化和连续性正弦变化的反应中所起的相对作用。实验使用了在有神经支配的颈动脉窦周围植入可变压力胶囊的清醒兔子。在胶囊压力发生阶跃变化后，在升压反应期间，血压变化中归因于心输出量变化的大致比例在2.5秒后为7%，10秒后为22%，在平台期为27%；在降压反应期间，相应比例分别为100%、8%和17%。在胶囊压力进行正弦变化期间，整个周期内血压变化的平均7%归因于心输出量的变化。