家兔心输出量变化对由颈动脉窦反射性诱发的动脉血压变化的影响。

The reflex cardiovascular effects of changes in pressure within the vascularly isolated carotid sinus were examined in seventeen anaesthetized rabbits. The opposite sinus was denervated and both aortic nerves were divided, 2. Comparison of the mean values at sinus pressures of 40 and 200 mmHg showed a large reduction in systemic arterial pressure from 126 to 58 mmHg and a moderate reduction in heart rate, from 287 to 253 beats min-1. Cardiac output, measured by thermal dilution, showed only a small change, a fall from 160 to 148 ml. min-1 kg-1. 3. By contrast with this reduction in cardiac output of just over 7%, total peripheral resistance, derived by dividing mean arterial pressure by cardiac output, was halved, falling from 0-48 to 0-41 mmHg ml.-1 min kg. 4. Thus in the anaesthetized rabbit changes in cardiac output make only a small contribution to the changes in systemic pressure evoked by alterations in carotid sinus pressure. Changes in total peripheral resistance are principally responsible for the effect on systemic pressure. 5. Though the changes in output of the heart were small, there were considerable changes in the work done by the left ventricle which was approximately halved when carotid sinus pressure was raised from 40 to 200 mmHg.

在17只麻醉兔身上研究了血管分离的颈动脉窦内压力变化的反射性心血管效应。对侧窦去神经支配，双侧主动脉神经切断。
比较40和200 mmHg窦压力下的平均值，结果显示全身动脉压大幅降低，从126 mmHg降至58 mmHg，心率适度降低，从287次/分钟降至253次/分钟。通过热稀释法测量的心输出量仅出现小幅度变化，从160 ml·min⁻¹·kg⁻¹降至148 ml·min⁻¹·kg⁻¹。
与心输出量仅略超过7%的降低形成对比的是，通过将平均动脉压除以心输出量得出的总外周阻力减半，从0.48 mmHg·ml⁻¹·min·kg降至0.41 mmHg·ml⁻¹·min·kg。
因此，在麻醉兔中，心输出量的变化对颈动脉窦压力改变引起的全身压力变化贡献很小。总外周阻力的变化是影响全身压力的主要原因。
虽然心脏输出量的变化很小，但左心室所做的功却有相当大的变化，当颈动脉窦压力从40 mmHg升高到200 mmHg时，左心室所做的功大约减半。

The contribution of alterations in cardiac output to changes in arterial pressure reflexly evoked from the carotid sinus in the rabbit.