Valora N, Bruno C, Floridi S, Mei V, Pranzetti P, Cherchi G M
Boll Soc Ital Biol Sper. 1981 Jun 30;57(12):1352-8.
Electrocardiographic changes induced by Verapamil, drug inducing inhibition of transmembrane movement of calcium into cardiac cells and mobilization of intracellular Ca++, have been studied in 10 anesthetized rats. Authors observed that Verapamil has: 1) negative chronotropic action on SA node; sometimes appears a superior nodal rhythm; 2) inconstantly, negative dromotropic action with prolonged atrioventricular conduction and "period of Luciani-Wenckebach'; 3) effective antiarrhythmic action; 4) no protective action towards peripheric vascular epinephrine effects; 5) remarkable negative inotropic action, whose Authors consider indirect signs the electrocardiographic changes, which indicate severe coronary failure, and the death of 6 rats by acute pulmonary edema.
在10只麻醉大鼠中研究了维拉帕米引起的心电图变化，维拉帕米是一种抑制钙离子跨膜进入心肌细胞并促使细胞内钙离子动员的药物。作者观察到维拉帕米具有：1）对窦房结有负性变时作用；有时会出现交界性心律；2）对传导性有不定的负性作用，伴有房室传导延长和“卢西亚尼-温克巴赫周期”；3）有效的抗心律失常作用；4）对外周血管肾上腺素效应无保护作用；5）显著的负性肌力作用，作者认为心电图变化的间接征象表明严重的冠状动脉功能衰竭，以及6只大鼠死于急性肺水肿。
