类风湿患者的长期环磷酰胺治疗：对血清巯基水平、锝指数、红细胞沉降率及临床反应的影响。
Long-term cyclophosphamide treatment in rheumatoid patients: effects on serum sulphydryl levels, technetium index, ESR and clinical response.
作者信息
Grimaldi M G
出版信息
Br J Clin Pharmacol. 1981 Oct;12(4):503-6. doi: 10.1111/j.1365-2125.1981.tb01257.x.
Abstract
1 After 12 months cyclophosphamide administration the serum sulphydryl concentrations increased in all of twelve rheumatoid patients treated, and returned towards the normal range in eleven. 2 A decrease was observed in the technetium index, the erythrocyte sedimentation rate, and joint count. 3 Long-term cyclophosphamide-induced serum SH increase may represent a specific change in the process of the rheumatoid disease activity, possibly involving the pathogenic B cells.
摘要
- 在给予环磷酰胺治疗12个月后，所有接受治疗的12名类风湿患者的血清巯基浓度均升高，其中11名患者的血清巯基浓度恢复至正常范围。2. 锝指数、红细胞沉降率和关节计数均下降。3. 长期使用环磷酰胺导致血清巯基增加可能代表类风湿疾病活动过程中的一种特定变化，可能涉及致病性B细胞。
相似文献
1
Long-term cyclophosphamide treatment in rheumatoid patients: effects on serum sulphydryl levels, technetium index, ESR and clinical response.类风湿患者的长期环磷酰胺治疗：对血清巯基水平、锝指数、红细胞沉降率及临床反应的影响。
Br J Clin Pharmacol. 1981 Oct;12(4):503-6. doi: 10.1111/j.1365-2125.1981.tb01257.x.
2
Long-term low dose ticlopidine treatment in rheumatoid arthritis: effects on serum sulphydryl levels, technetium index, erythrocyte sedimentation rate, and clinical disease activity.类风湿关节炎的长期低剂量噻氯匹定治疗：对血清巯基水平、锝指数、红细胞沉降率及临床疾病活动度的影响
Eur J Clin Pharmacol. 1985;29(2):165-8. doi: 10.1007/BF00547416.
3
Serum sulfhydryl levels in rheumatoid patients treated with cyclophosphamide.接受环磷酰胺治疗的类风湿患者的血清巯基水平。
Scand J Rheumatol. 1980;9(4):237-40. doi: 10.3109/03009748009112355.
4
Long-term low dose haloperidol treatment in rheumatoid patients: effects on serum sulphydryl levels, technetium index, ESR, and clinical response.类风湿患者长期低剂量氟哌啶醇治疗：对血清巯基水平、锝指数、红细胞沉降率及临床反应的影响。
Br J Clin Pharmacol. 1981 Oct;12(4):579-81. doi: 10.1111/j.1365-2125.1981.tb01268.x.
5
Serum sulfhydryl levels in rheumatoid patients treated with haloperidol.接受氟哌啶醇治疗的类风湿患者的血清巯基水平。
Scand J Rheumatol. 1980;9(4):225-8. doi: 10.3109/03009748009112352.
6
Serum sulphydryl levels in rheumatoid patients treated with alclofenac.用阿氯芬酸治疗的类风湿患者的血清巯基水平。
Curr Med Res Opin. 1975;3(5):268-75. doi: 10.1185/03007997509114777.
7
Controlled trial of cyclophosphamide in rheumatoid arthritis.环磷酰胺治疗类风湿关节炎的对照试验。
Arthritis Rheum. 1976 May-Jun;19(3):563-73. doi: 10.1002/art.1780190308.
8
Immunologic effects of cyclophosphamide treatment in rheumatoid arthritis.环磷酰胺治疗类风湿关节炎的免疫学效应
Arthritis Rheum. 1970 Nov-Dec;13(6):754-60. doi: 10.1002/art.1780130604.
9
10
Serum sulphydryl concentrations and antirheumatic drugs in rheumatoid patients.类风湿患者的血清巯基浓度与抗风湿药物
J Pharm Pharmacol. 1980 Dec;32(12):876. doi: 10.1111/j.2042-7158.1980.tb13103.x.
引用本文的文献
1
Long-term low dose ticlopidine treatment in rheumatoid arthritis: effects on serum sulphydryl levels, technetium index, erythrocyte sedimentation rate, and clinical disease activity.类风湿关节炎的长期低剂量噻氯匹定治疗：对血清巯基水平、锝指数、红细胞沉降率及临床疾病活动度的影响
Eur J Clin Pharmacol. 1985;29(2):165-8. doi: 10.1007/BF00547416.
本文引用的文献
1
Tissue sulfhydryl groups.组织巯基
Arch Biochem Biophys. 1959 May;82(1):70-7. doi: 10.1016/0003-9861(59)90090-6.
2
3
Serum sulphydryl concentrations and antirheumatic drugs in rheumatoid patients.类风湿患者的血清巯基浓度与抗风湿药物
J Pharm Pharmacol. 1980 Dec;32(12):876. doi: 10.1111/j.2042-7158.1980.tb13103.x.
4
On the effects of antirheumatic drugs on protein sulphydryl reactivity in human serum.抗风湿药物对人血清中蛋白质巯基反应性的影响
J Pharm Pharmacol. 1980 Apr;32(4):301-2. doi: 10.1111/j.2042-7158.1980.tb12920.x.
5
Enhancement of antibody synthesis in vitro by mercaptoethanol.巯基乙醇对体外抗体合成的增强作用。
Cell Immunol. 1972 Jan;3(1):156-60. doi: 10.1016/0008-8749(72)90237-7.
6
The effect of 2-mercaptoethanol on murine mixed lymphocyte cultures.2-巯基乙醇对小鼠混合淋巴细胞培养的影响。
J Exp Med. 1974 Apr 1;139(4):1025-30. doi: 10.1084/jem.139.4.1025.
7
Promotion of replication in lymphoid cells by specific thiols and disulfides in vitro. Effects on mouse lymphoma cells in comparison with splenic lymphocytes.体外特定硫醇和二硫化物对淋巴样细胞复制的促进作用。与脾淋巴细胞相比，对小鼠淋巴瘤细胞的影响。
J Exp Med. 1973 Sep 1;138(3):574-92. doi: 10.1084/jem.138.3.574.
8
Cyclophosphamide: use in practice.环磷酰胺：实际应用
Ann Intern Med. 1974 Apr;80(4):531-40. doi: 10.7326/0003-4819-80-4-531.
9
Chemical modulation of cell surfaces by sulfhydryl compounds: effect on C3b receptors.巯基化合物对细胞表面的化学调节作用：对C3b受体的影响
J Immunol. 1974 Sep;113(3):940-7.
10
Sulfhydryl deficiency in connective tissue disorders: correlation with disease activity and protein alterations.
Metabolism. 1971 May;20(5):446-55. doi: 10.1016/0026-0495(71)90120-x.
Zotero 插件