Lavania U C, Sharma A K
Biosystems. 1981;14(2):171-8. doi: 10.1016/0303-2647(81)90066-6.
A model for the spatial relationship of the arrangement of the chromosomes in the nucleus in eukaryota is presented. Evidence is derived from light and electron microscopic studies, application of autoradiographic and banding techniques; on the organization, structure and behaviour of chromosomes during interphase and other stages of cell cycle. This model visualizes the entire chromosomal DNA as a single uninemic multirepliconic continuum where the chromosomes with their centromeres and telomeres have a predetermined arrangement among themselves as well as in relation to the nucleolus and nuclear membrane. This orderly arrangement is presumably maintained through interchromosomal connections. The impact of this model on the interpretation of various cytogenetic phenomena is discussed.
提出了一个真核生物细胞核中染色体排列空间关系的模型。证据来源于光学显微镜和电子显微镜研究、放射自显影和显带技术的应用；关于染色体在间期和细胞周期其他阶段的组织、结构和行为。该模型将整个染色体DNA视为一个单一的单线性多复制子连续体，其中带有着丝粒和端粒的染色体在它们自身之间以及相对于核仁和核膜具有预先确定的排列。这种有序排列大概是通过染色体间连接维持的。讨论了该模型对各种细胞遗传学现象解释的影响。
