Blackett N M, Botnick L E
Blood Cells. 1981;7(2):417-43.
Large changes in the pattern of regeneration of haemopoietic progenitor cells (CFU-S) are reported as a result of simply altering the time interval between administration of certain cytotoxic agents and whole-body irradiation. These results suggest a negative feedback control for the number of CFU-S, which has an appreciable time delay. A high inverse correlation between the number of maturing granulocytic cells (with ring-shaped nuclei) at the time of irradiation and the subsequent regeneration of CFU-S is consistent with these cells producing some substance that controls the number but not the proliferation rate of the CFU-S. The possibility is considered that this mechanism is an important control in the biological regulation of haemopoiesis.
据报道，仅仅改变某些细胞毒性药物给药与全身照射之间的时间间隔，造血祖细胞（CFU-S）的再生模式就会发生巨大变化。这些结果表明，CFU-S数量存在负反馈控制，且具有明显的时间延迟。照射时成熟粒细胞（核呈环状）数量与随后CFU-S的再生之间存在高度负相关，这与这些细胞产生某种控制CFU-S数量而非增殖速率的物质是一致的。人们认为这种机制可能是造血生物学调节中的一种重要控制方式。
