The pharmacokinetics and metabolism of the anilide local anaesthetics in neonates. III. Mepivacaine.

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作者信息

Moore R G, Thomas J, Triggs E J, Thomas D B, Burnard E D, Shanks C A

出版信息

Eur J Clin Pharmacol. 1978 Nov 27;14(3):203-12. doi: 10.1007/BF02089961.

DOI:10.1007/BF02089961

PMID:729615

Abstract

摘要

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The pharmacokinetics and metabolism of the anilide local anaesthetics in neonates. III. Mepivacaine.

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Shortcomings in pharmacokinetic analysis by conceiving the body to exhibit properties of a single compartment.将人体视为具有单室性质进行药代动力学分析时存在的缺点。

J Pharm Sci. 1968 Jan;57(1):117-23. doi: 10.1002/jps.2600570123.

Binding of anilide-type local anesthetics in human plasma. I. Relationships between binding, physicochemical properties, and anesthetic activity.酰苯胺类局部麻醉药在人血浆中的结合。I. 结合、物理化学性质与麻醉活性之间的关系。

Anesthesiology. 1970 Sep;33(3):287-303. doi: 10.1097/00000542-197009000-00002.

Disposition kinetics of lidocaine in normal subjects.

Ann N Y Acad Sci. 1971 Jul 6;179:383-98. doi: 10.1111/j.1749-6632.1971.tb46915.x.

Aromatic hydroxylation of lidocaine and mepivacaine in rats and humans.利多卡因和甲哌卡因在大鼠及人体中的芳香族羟基化作用。

J Med Chem. 1972 Oct;15(10):1046-9. doi: 10.1021/jm00280a013.

Clearance concepts in pharmacokinetics.药代动力学中的清除概念。

J Pharmacokinet Biopharm. 1973 Apr;1(2):123-36. doi: 10.1007/BF01059626.

Clearance and metabolism of mepivacaine in the human neonate.甲哌卡因在人类新生儿体内的清除率与代谢情况。

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