Fichtl B, Kurz H
Eur J Clin Pharmacol. 1978 Dec 18;14(5):335-40. doi: 10.1007/BF00611903.
Binding of 22 drugs to human muscle tissue has been determined by ultrafiltration. All drugs tested were bound, the bound fraction ranging from 13% (aminophenazone) to greater than 98% (desipramine). Both linear and nonlinear binding was observed. For chemically related substances, binding to muscle tissue correlated with plasma binding and lipid solubility. There were significant differences in binding to muscle from different individuals. With respect to pharmacokinetics of drugs, it is suggested that binding to muscle tissue may be at least as important as plasma binding.
通过超滤法测定了22种药物与人体肌肉组织的结合情况。所有测试药物均有结合，结合分数范围从13%（氨基苯酮）到大于98%（地昔帕明）。观察到了线性和非线性结合。对于化学相关物质，其与肌肉组织的结合与血浆结合及脂溶性相关。不同个体的肌肉结合存在显著差异。关于药物的药代动力学，有人提出药物与肌肉组织的结合可能至少与血浆结合同样重要。
