多巴胺代谢产物在评估作用于多巴胺能神经元的药物中的意义。
Significance of dopamine metabolites in the evaluation of drugs acting on dopaminergic neurons.
作者信息
Di Giulio A M, Groppetti A, Cattabeni F, Galli C L, Maggi A, Algeri S, Ponzio F
出版信息
Eur J Pharmacol. 1978 Nov 15;52(2):201-7. doi: 10.1016/0014-2999(78)90207-8.
The effect of various drugs was studied on 3-methoxytyramine (3-MT) concentrations in rat striatum. The drugs were chosen for their ability to interfere with the dopaminergic system at different levels. Dopamine (DA) acidic metabolites, i.e. homovanillic acid (HVA) and 3,4-dihydroxyphenylacetic acid (DOPAC), were also measured. Changes of 3-MT, unlike those of DOPAC and HVA, seem to reflect the functional activity of dopaminergic neurons. In fact drugs believed to increase or decrease DA content in the synaptic cleft produce predictable changes of striatal 3-MT. Thus cocaine, nomifensine and d-amphetamine increase 3-MT concentrations while gamma-butyrolactone, alpha-methyltyrosine and apomorphine decrease it.
研究了各种药物对大鼠纹状体中3-甲氧基酪胺（3-MT）浓度的影响。选择这些药物是因为它们能够在不同水平干扰多巴胺能系统。还测量了多巴胺（DA）的酸性代谢产物，即高香草酸（HVA）和3,4-二羟基苯乙酸（DOPAC）。与DOPAC和HVA不同，3-MT的变化似乎反映了多巴胺能神经元的功能活性。事实上，据信增加或减少突触间隙中DA含量的药物会使纹状体3-MT产生可预测的变化。因此，可卡因、诺米芬辛和d-苯丙胺会增加3-MT浓度，而γ-丁内酯、α-甲基酪氨酸和阿扑吗啡则会降低其浓度。
Zotero 插件