Baker D, Constable W, Elkon D, Rinehart L
Cancer. 1981 Nov 15;48(10):2179-83. doi: 10.1002/1097-0142(19811115)48:10<2179::aid-cncr2820481011>3.0.co;2-u.
Courses of irradiation consisting of 6000 rad in ten equal fractions over 12 days delivered to KHT sarcomas in mice controlled 55% of the local tumors but 83% of the mice died from metastases. Three strategies to reduce the risk of metastatic spread were tested. The fractionation scheme was changed to deliver the same total dose using a large initial fraction followed by seven equal portions with the same overall time. ICRF-159 was used with the intention of partially synchronizing the tumor growth fraction in a radiosensitive state of the growth cycle and of promoting normalization of the tumor vasculature. Levamisole was used to stimulate the immune system. The combination of ICRF-159 with the eight-fraction radiation course proved to be effective for both increasing local control and decreasing the incidence of metastases. The addition of levamisole did not improve the results obtained with a combination of ICRF-159 and irradiation.
对小鼠KHT肉瘤进行的放射治疗疗程为在12天内分10等份给予6000拉德,该治疗控制了55%的局部肿瘤,但83%的小鼠死于转移。测试了三种降低转移扩散风险的策略。改变了分割方案,在相同的总时间内,先给予一个大的初始剂量,然后分七等份给予相同的总剂量。使用ICRF - 159的目的是使肿瘤生长部分在生长周期的放射敏感状态下部分同步,并促进肿瘤血管系统正常化。使用左旋咪唑来刺激免疫系统。事实证明,ICRF - 159与八分割放射疗程相结合对于提高局部控制率和降低转移发生率均有效。添加左旋咪唑并没有改善ICRF - 159与放射治疗相结合所取得的效果。