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ICRF - 159和左旋咪唑对实体瘤局部照射后转移发生率的影响。

The influence of ICRF-159 and levamisole on the incidence of metastases following local irradiation of a solid tumor.

作者信息

Baker D, Constable W, Elkon D, Rinehart L

出版信息

Cancer. 1981 Nov 15;48(10):2179-83. doi: 10.1002/1097-0142(19811115)48:10<2179::aid-cncr2820481011>3.0.co;2-u.

DOI:10.1002/1097-0142(19811115)48:10<2179::aid-cncr2820481011>3.0.co;2-u
PMID:7296476
Abstract

Courses of irradiation consisting of 6000 rad in ten equal fractions over 12 days delivered to KHT sarcomas in mice controlled 55% of the local tumors but 83% of the mice died from metastases. Three strategies to reduce the risk of metastatic spread were tested. The fractionation scheme was changed to deliver the same total dose using a large initial fraction followed by seven equal portions with the same overall time. ICRF-159 was used with the intention of partially synchronizing the tumor growth fraction in a radiosensitive state of the growth cycle and of promoting normalization of the tumor vasculature. Levamisole was used to stimulate the immune system. The combination of ICRF-159 with the eight-fraction radiation course proved to be effective for both increasing local control and decreasing the incidence of metastases. The addition of levamisole did not improve the results obtained with a combination of ICRF-159 and irradiation.

摘要

对小鼠KHT肉瘤进行的放射治疗疗程为在12天内分10等份给予6000拉德,该治疗控制了55%的局部肿瘤,但83%的小鼠死于转移。测试了三种降低转移扩散风险的策略。改变了分割方案,在相同的总时间内,先给予一个大的初始剂量,然后分七等份给予相同的总剂量。使用ICRF - 159的目的是使肿瘤生长部分在生长周期的放射敏感状态下部分同步,并促进肿瘤血管系统正常化。使用左旋咪唑来刺激免疫系统。事实证明,ICRF - 159与八分割放射疗程相结合对于提高局部控制率和降低转移发生率均有效。添加左旋咪唑并没有改善ICRF - 159与放射治疗相结合所取得的效果。

相似文献

1
The influence of ICRF-159 and levamisole on the incidence of metastases following local irradiation of a solid tumor.ICRF - 159和左旋咪唑对实体瘤局部照射后转移发生率的影响。
Cancer. 1981 Nov 15;48(10):2179-83. doi: 10.1002/1097-0142(19811115)48:10<2179::aid-cncr2820481011>3.0.co;2-u.
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The influence of warfarin of levamisole on the incidence of metastases following local irradiation of a solid tumor.
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The influence of levamisole and hyperthermia on the incidence of metastases from an X-irradiated tumor.
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Dose local x-irradiation of a tumor increase the incidence of metastases?
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ICRF-159 enhancement of radiation response in combined modality therapies. I. Time/dose relationships for tumour response.ICRF - 159对联合治疗中放射反应的增强作用。I. 肿瘤反应的时间/剂量关系。
Br J Cancer. 1979 May;39(5):516-23. doi: 10.1038/bjc.1979.95.
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Radiotherapy combined with ICRF 159 (NSC 129943).放射疗法联合ICRF 159(NSC 129943)。
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Influence of ICRF 159 and trition WR 1339 on metastases of a rat epithelioma.ICRF 159和曲菌素WR 1339对大鼠上皮瘤转移的影响。
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Studies in mice treated with ICRF-159 combined with daunorubicin or doxorubicin.对用ICRF - 159联合柔红霉素或阿霉素处理的小鼠进行的研究。
Cancer Treat Rep. 1981 Mar-Apr;65(3-4):267-76.

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Clin Exp Metastasis. 2008;25(1):75-80. doi: 10.1007/s10585-007-9103-9. Epub 2007 Oct 12.
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Radiation enhancement of metastasis: a review.
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