6-羟基多巴胺和利血平对心肌腺苷酸环化酶的慢性影响。

Chronic effects of 6-hydroxydopamine and reserpine on myocardial adenylate cyclase.

作者信息

Chiu T H

出版信息

Eur J Pharmacol. 1978 Dec 1;52(3-4):385-8. doi: 10.1016/0014-2999(78)90294-7.

Abstract

The effects of chronic administration of 6-hydroxydopamine or reserpine on catecholamine-sensitive adenylate cyclase from rat hearts were studied. Not only basal adenylate cyclase activity, but stimulation of the enzyme by norepinephrine, isoproterenol, NaF, guanylyl-imidodiphosphate, or combination of isoproterenol and guanylyl-imidodiphosphate, was significantly increased in the treated than in the control hearts. It is inferred that supersensitivity of myocardial adenylate cyclase following chronic treatment with reserpine or 6-hydroxydopamine may result from an increase in the catalytic activity of the enzyme.

摘要

研究了长期给予6-羟基多巴胺或利血平对大鼠心脏儿茶酚胺敏感性腺苷酸环化酶的影响。与对照心脏相比，不仅基础腺苷酸环化酶活性，而且去甲肾上腺素、异丙肾上腺素、氟化钠、鸟苷酰亚胺二磷酸或异丙肾上腺素与鸟苷酰亚胺二磷酸组合对该酶的刺激作用在处理后的心脏中均显著增加。据推测，利血平或6-羟基多巴胺长期处理后心肌腺苷酸环化酶的超敏感性可能是由于该酶催化活性的增加所致。