N-亚硝基西咪替丁对培养的哺乳动物细胞姐妹染色单体交换和染色体畸变的诱导作用。
Induction of sister chromatid exchanges and chromosome aberrations in cultured mammalian cells by N-nitrosocimetidine.
作者信息
Athanasiou K, Kyrtopoulos S A
出版信息
Cancer Lett. 1981 Oct;14(1):71-5. doi: 10.1016/0304-3835(81)90011-2.
PMID:7296544
Abstract
N-Nitrosocimetidine (NC) induces significant numbers of sister chromatid exchanges (SCE) and chromosome aberrations in cultured Chinese hamster ovary (CHO) cells even at a concentration of 1.2 x 10(-7) M. Its effectiveness in SCE induction is about two thirds that of the gastric carcinogen N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). These results constitute further evidence that NC possesses carcinogenic activity.
摘要
N-亚硝基西咪替丁（NC）即使在浓度为1.2×10⁻⁷ M时，也会在培养的中国仓鼠卵巢（CHO）细胞中诱导大量的姐妹染色单体交换（SCE）和染色体畸变。其诱导SCE的效力约为胃致癌物N-甲基-N'-硝基-N-亚硝基胍（MNNG）的三分之二。这些结果进一步证明NC具有致癌活性。
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