Athanasiou K, Kyrtopoulos S A
Cancer Lett. 1981 Oct;14(1):71-5. doi: 10.1016/0304-3835(81)90011-2.
N-Nitrosocimetidine (NC) induces significant numbers of sister chromatid exchanges (SCE) and chromosome aberrations in cultured Chinese hamster ovary (CHO) cells even at a concentration of 1.2 x 10(-7) M. Its effectiveness in SCE induction is about two thirds that of the gastric carcinogen N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). These results constitute further evidence that NC possesses carcinogenic activity.
N-亚硝基西咪替丁（NC）即使在浓度为1.2×10⁻⁷ M时，也会在培养的中国仓鼠卵巢（CHO）细胞中诱导大量的姐妹染色单体交换（SCE）和染色体畸变。其诱导SCE的效力约为胃致癌物N-甲基-N'-硝基-N-亚硝基胍（MNNG）的三分之二。这些结果进一步证明NC具有致癌活性。
