• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Induction of chromosome damage by methylene chloride in CHO cells.

作者信息

Thilagar A K, Kumaroo V

出版信息

Mutat Res. 1983 Mar;116(3-4):361-7. doi: 10.1016/0165-1218(83)90074-5.

DOI:10.1016/0165-1218(83)90074-5
PMID:6835252
Abstract

The genotoxicity of methylene chloride was determined using sister-chromatid exchange (SCE) and chromosome aberration assays in cultured Chinese hamster ovary (CHO) cells. Methylene chloride caused extensive chromosome aberrations both with and without metabolic activation. However, the results of the SCE assay were negative for methylene chloride. These results agree with previously observed genotoxic effects of methylene chloride in Salmonella typhimurium and Saccharomyces cerevisiae. The fact that methylene chloride causes chromosome aberrations without increasing the SCE level indicates that complete reliance on the induction of SCE as a test system for assessing chromosomal effects is not valid.

摘要

相似文献

1
Induction of chromosome damage by methylene chloride in CHO cells.
Mutat Res. 1983 Mar;116(3-4):361-7. doi: 10.1016/0165-1218(83)90074-5.
2
Genotoxicity testing of extracts of a Swedish moist oral snuff.一种瑞典湿鼻烟提取物的遗传毒性测试。
Mutat Res. 1991 Oct;261(2):101-15. doi: 10.1016/0165-1218(91)90056-r.
3
Induction of sister chromatid exchanges and chromosome aberrations in cultured mammalian cells by N-nitrosocimetidine.N-亚硝基西咪替丁对培养的哺乳动物细胞姐妹染色单体交换和染色体畸变的诱导作用。
Cancer Lett. 1981 Oct;14(1):71-5. doi: 10.1016/0304-3835(81)90011-2.
4
The effects of 4CMB, 4HMB and BC on SCE, chromosome aberration and point mutation in cultured Chinese hamster ovary cells.4-氯-3-甲基苯甲酸（4CMB）、4-羟基-3-甲基苯甲酸（4HMB）和苯甲酸（BC）对培养的中国仓鼠卵巢细胞姐妹染色单体交换（SCE）、染色体畸变及点突变的影响。
Mutat Res. 1982 Jan-Feb;100(1-4):263-9. doi: 10.1016/0165-1218(82)90058-1.
5
Sister-chromatid exchange and chromosomal aberration induction in cultured Chinese hamster cells by the monomethylbenz[a]anthracenes.
Mutat Res. 1982 Sep;102(2):173-82. doi: 10.1016/0165-1218(82)90117-3.
6
Chromosome aberrations and sister chromatid exchanges in Chinese hamster ovary cells: evaluations of 108 chemicals.中国仓鼠卵巢细胞中的染色体畸变和姐妹染色单体交换：对108种化学物质的评估
Environ Mol Mutagen. 1987;10 Suppl 10:1-175. doi: 10.1002/em.2850100502.
7
Chromosomal instability in an oxygen-tolerant variant of Chinese hamster ovary cells.中国仓鼠卵巢细胞耐氧变体中的染色体不稳定性。
Mutat Res. 1989 Jan;219(1):17-28. doi: 10.1016/0921-8734(89)90037-4.
8
O-esters of N-acylhydroxylamines: toxicity and enhancement of sister-chromatid exchange in Chinese hamster ovary cells.
Mutat Res. 1981 Jan;88(1):81-8. doi: 10.1016/0165-1218(81)90092-6.
9
Induction of 6-thioguanine resistance, chromosome aberrations and SCE by dinitropyrenes in Chinese hamster ovary cells in vitro.
Mutat Res. 1985 Dec;158(3):209-15. doi: 10.1016/0165-1218(85)90087-4.
10
Chromosome damage and SCE induced by the cytostatic factor homo-aza-steroidal ester of P-bis (2-chloro-ethyl) amino phenyl acetic acid in CHO cells in culture.在培养的中国仓鼠卵巢（CHO）细胞中，由细胞生长抑制剂对双（2-氯乙基）氨基苯基乙酸的高氮杂甾体酯诱导的染色体损伤和姐妹染色单体交换。
Environ Mutagen. 1983;5(3):279-83. doi: 10.1002/em.2860050306.

引用本文的文献

1
Induction of chromosomal aberrations in the mussel Mytilus galloprovincialis watch.
Bull Environ Contam Toxicol. 1985 Nov;35(5):660-5. doi: 10.1007/BF01636570.