Nève P, Authelet M, Golstein J
Cell Tissue Res. 1981;220(3):499-509. doi: 10.1007/BF00216753.
The effect of aging on the morphology and function of the thyroid gland of the cream hamster was studied by light and electron microscopy coupled with autoradiography or histochemistry. Morphologically, aging induces an accumulation of lysosomal dense bodies and a loss of the phagocytosis of colloid droplets after stimulation with TSH. Iodine uptake and organification occur normally and thyroglobulin synthesis, estimated by autoradiography with 3H-leucine, is not different from that observed in young animals. The basal T4 and T3 plasma levels are lower in the old animals. A low iodine diet administered for several months prevents the age related accumulation of lysosomal dense bodies. Hormone secretion seems to proceed by two different mechanisms; phagocytosis of colloid droplets, the classical mechanism that decreases with age, and an additional mechanism, probably micropinocytosis, that is maintained during the whole lifespan.
通过光学显微镜、电子显微镜结合放射自显影或组织化学方法，研究了衰老对金黄仓鼠甲状腺形态和功能的影响。形态学上，衰老会导致溶酶体致密小体的积累，以及在促甲状腺激素刺激后胶体小滴吞噬作用的丧失。碘摄取和有机化正常发生，用³H-亮氨酸放射自显影估计的甲状腺球蛋白合成与幼龄动物中观察到的情况没有差异。老年动物的基础血浆T4和T3水平较低。给予低碘饮食数月可防止与年龄相关的溶酶体致密小体积累。激素分泌似乎通过两种不同机制进行；胶体小滴的吞噬作用，这是随着年龄增长而减少的经典机制，以及一种额外的机制，可能是微胞饮作用，其在整个生命周期中都得以维持。
