Szepesházi K, Lapis K, Jeney A, Szende B, Schawartz J, Ujhelyi E, Takács J, Kovalszky I, Tompa A
Exp Pathol (Jena). 1978;15(5):271-87. doi: 10.1016/s0014-4908(78)80067-2.
The liver protective effect of Aicaphosphate in CC1(4)-induced acute, as well as CC1(4)-and thioacetamide-induced subacute and chronic liver damages is demonstrated. The effect of the protective drugs was studied in the forms of pre-, simultaneous and delayed treatment in acute and chronic liver damages induced by various toxic agents. The degree of liver damage was determined by morphological and biochemical methods, complementary to each other. For the completion of histological studies and morphometry used for the determination of the degree of fibrosis biochemical investigations are performed. In acute liver damage the determination of DNA, protein and lipid contents of the liver tissue and the radioactive aminoacid incorporation rate should be carried out with a simultaneous analysis of the serum enzymes. In chronic liver damage, the measurement of the hydroxyproline and DNA contents of the liver give useful data for the determination of the severity of the lesion and the effect of the protective drugs, respectively.
已证实磷丙泊酚对四氯化碳诱导的急性肝损伤以及四氯化碳和硫代乙酰胺诱导的亚急性和慢性肝损伤具有肝脏保护作用。在由各种毒性剂诱导的急性和慢性肝损伤中，以预处理、同时处理和延迟处理的形式研究了保护药物的作用。肝损伤程度通过相互补充的形态学和生化方法来确定。为了完成用于确定纤维化程度的组织学研究和形态计量学，需进行生化研究。在急性肝损伤中，应测定肝组织的DNA、蛋白质和脂质含量以及放射性氨基酸掺入率，并同时分析血清酶。在慢性肝损伤中，测量肝脏的羟脯氨酸和DNA含量分别可为确定病变严重程度和保护药物的效果提供有用数据。
