丙磺舒对豚鼠离体心脏的动力学及变力作用
Kinetics and inotropic action of probenecid in guinea-pig heart in vitro.
作者信息
Erttmann R R
出版信息
Experientia. 1978 Dec 15;34(12):1620-1. doi: 10.1007/BF02034712.
PMID:729735
Abstract
Probenecid (100-750 microgram . ml-1) was found to inhibit cardiac contraction force in untreated and digoxin-treated (100 microgram . ml-1) isolated right guinea-pig atrium in vitro by a reversible process, without influencing beating frequency. At low concentrations (1.5--60 microgram . ml-1), 14C-probenecid was accumulated into right atrium by an oxygen-dependent process. Correlation between uptake and negative inotropic action of probenecid could not be found.
摘要
丙磺舒（100 - 750微克·毫升⁻¹）被发现可通过可逆过程抑制未处理及地高辛处理（100微克·毫升⁻¹）的离体豚鼠右心房的心肌收缩力，且不影响搏动频率。在低浓度（1.5 - 60微克·毫升⁻¹）时，¹⁴C - 丙磺舒通过氧依赖过程蓄积到右心房。未发现丙磺舒摄取与负性肌力作用之间的相关性。
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